![]() ![]() However, dialysis before admission, the most heavily weighted factor in ABCD-10, performed weaker in this cohort (odds ratio, 3.7 95% CI, 1.0-13.2, P =. All risk factors in ABCD-10 were significantly associated with in-hospital mortality. Discrimination and calibration of each risk score were assessed and compared using the area under the receiver operating characteristic curve and calibration plot, respectively.Īmong 196 patients (median age, 56 years 116 women ), 45 (23.0%) did not survive to discharge. This retrospective cohort study was conducted over a 17-year period from January 2003 to March 2019 and included 196 patients with epidermal necrolysis who were recruited from Singapore General Hospital, the national referral center for epidermal necrolysis. To assess ABCD-10 among patients in a contemporary Asian cohort and compare its performance with the Score of Toxic Epidermal Necrosis (SCORTEN) and study the associations of time and immunomodulatory therapy with the performance of ABCD-10 and SCORTEN. However, to our knowledge, it remains to be externally validated in other cohorts. The ABCD-10 score (age, bicarbonate, cancer, dialysis, 10% body surface area), a new prognostic score for mortality in epidermal necrolysis, was recently developed and validated in the US. Epidermal necrolysis is a rare severe cutaneous drug reaction associated with high mortality. Learn about clinical trials currently looking for people with Kennedy's disease at. ![]() How can I or my loved one help improve care for people with Kennedy's disease?Ĭonsider participating in a clinical trial so clinicians and scientists can learn more about Kennedy's disease and related disorders. Clinical research uses human volunteers to help researchers learn more about a disorder and perhaps find better ways to safely detect, treat, or prevent disease.Īll types of volunteers are needed- those who are healthy or may have an illness or disease- of all different ages, sexes, races, and ethnicities to ensure that study results apply to as many people as possible, and that treatments will be safe and effective for everyone who will use them.įor information about participating in clinical research visit NIH Clinical Research Trials and You. The life span of individuals with Kennedy's disease is usually normal. Individuals tend to remain ambulatory until late in the disease, although some may use mobility devices such as wheelchairs during later stages. Physical therapy and rehabilitation to slow muscle weakness and atrophy may prove helpful. Parents with concerns may wish to talk to a genetic counselor.Ĭurrently, there is no known cure for Kennedy's disease. Female children of people with Kennedy's disease are also carriers and have a 50 percent chance of having a male child affected with the disease. Kennedy's disease is an x-linked recessive disease, which means the female parent carries the defective gene on one X chromosomes. Others develop non-insulin-dependent diabetes mellitus. Some individuals develop gynecomastia (excessive enlargement of male breasts) and low sperm count or infertility. Weakness of the facial and tongue muscles may occur later in the course of the disease and often leads to dysphagia (difficulty in swallowing), dysarthria (slurring of speech), and recurrent aspiration pneumonia.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |